Eastern South Dakota Vacations from $422
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Your Eastern South Dakota Vacation
Locking in one of our vacation packages to Eastern South Dakota makes it a breeze to see and do more. Get set to experience this exciting destination's rural countryside and beyond. Your trip to Eastern South Dakota wouldn't be complete without getting to some of its best cities, starting with Sioux Falls. Some of the most popular attractions here include Denny Sanford Premier Center and Empire Mall. Mitchell is another favorite with Eastern South Dakota travelers. Visitors to this exciting destination enjoy Corn Palace and Mitchell Aquatic Center. Start packing your bags, because your Eastern South Dakota vacation is just a few clicks away with Expedia.
The Latest Eastern South Dakota vacation packages
Ramada by Wyndham Sioux Falls
Reviewed on Aug 20, 2025
Historic Twin Tudors Inn
Reviewed on Jun 16, 2025
AmericInn by Wyndham Sioux Falls North
Reviewed on Aug 24, 2025
Where to stay in Eastern South Dakota
Downtown Sioux Falls
While visiting Downtown Sioux Falls, you might make a stop by sights like Washington Pavilion of Arts and Science and Michelangelo's David.
Discover the most popular places to visit in Eastern South Dakota
Falls Park
Falls Park is just one of the places to see in Sioux Falls, so why not enjoy the other things to explore during your travels? Attend a sporting event or discover the area's beautiful waterfalls.
Corn Palace
You can find out about the history of Mitchell with a stop at Corn Palace. While in this family-friendly area, you can savor the top-notch restaurants.
Great Plains Zoo
Why not visit the native and exotic animals who live at Great Plains Zoo during your travels in Sioux Falls? Attend a sporting event or discover the area's beautiful waterfalls.
Eastern South Dakota Hotel Deals
Hotel On Phillips
Reviewed on Aug 23, 2025
Days Inn by Wyndham Sioux Falls Empire
Reviewed on Aug 23, 2025
Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr
Reviewed on Aug 22, 2025
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