Eastern South Dakota Vacations from $422

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Your Eastern South Dakota Vacation

Locking in one of our vacation packages to Eastern South Dakota makes it a breeze to see and do more. Get set to experience this exciting destination's rural countryside and beyond. Your trip to Eastern South Dakota wouldn't be complete without getting to some of its best cities, starting with Sioux Falls. Some of the most popular attractions here include Denny Sanford Premier Center and Empire Mall. Mitchell is another favorite with Eastern South Dakota travelers. Visitors to this exciting destination enjoy Corn Palace and Mitchell Aquatic Center. Start packing your bags, because your Eastern South Dakota vacation is just a few clicks away with Expedia.

The Latest Eastern South Dakota vacation packages

Price found within the past 48 hours. Click for updated prices.
Ramada by Wyndham Sioux Falls
Historic Twin Tudors Inn
AmericInn by Wyndham Sioux Falls North
Valley Inn
Gateway Park Hotel and Suites
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Where to stay in Eastern South Dakota

Find the best Eastern South Dakota areas and neighborhoods for the activities you enjoy most. Learn more about Eastern South Dakota

Discover the most popular places to visit in Eastern South Dakota

Eastern South Dakota Hotel Deals

Hotel On Phillips

Hotel On Phillips

2.5 out of 5
100 N Phillips Ave, Sioux Falls, SD
Fully refundableReserve now, pay when you stay
$188 nightly
The price is $208 total per night from Sep 1 to Sep 2
$208 total
Sep 1 - Sep 2
Total with taxes and fees
9.4/10 Exceptional! (1,152 reviews)
"Lovely location"

Reviewed on Aug 23, 2025

Hotel On Phillips
Days Inn by Wyndham Sioux Falls Empire

Days Inn by Wyndham Sioux Falls Empire

2 out of 5
3401 Gateway Blvd, I-29 and 41st Street Exit 77, Sioux Falls, SD
Fully refundableReserve now, pay when you stay
$60 nightly
The price is $68 total per night from Sep 3 to Sep 4
$68 total
Sep 3 - Sep 4
Total with taxes and fees
7.6/10 Good! (1,002 reviews)
"The only thing that could have been better was the breakfast choices. Some pastries, bagels, yogurt and fruit would have been nice."

Reviewed on Aug 23, 2025

Days Inn by Wyndham Sioux Falls Empire
Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr

Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr

3 out of 5
1301 West Russell, I-29 and Exit 81, Sioux Falls, SD
Fully refundableReserve now, pay when you stay
$70 nightly
The price is $78 total per night from Aug 27 to Aug 28
$78 total
Aug 27 - Aug 28
Total with taxes and fees
7.6/10 Good! (1,356 reviews)
"Fun waterpark in the hotel, and good restaurant."

Reviewed on Aug 22, 2025

Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.