Eastern South Dakota Vacations from $533
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Your Eastern South Dakota Vacation
Locking in one of our vacation packages to Eastern South Dakota makes it a breeze to see and do more. Get set to experience this exciting destination's rural countryside and beyond. Your trip to Eastern South Dakota wouldn't be complete without getting to some of its best cities, starting with Sioux Falls. Some of the most popular attractions here include Denny Sanford Premier Center and Empire Mall. Mitchell is another favorite with Eastern South Dakota travelers. Visitors to this exciting destination enjoy Corn Palace and Mitchell Aquatic Center. Start packing your bags, because your Eastern South Dakota vacation is just a few clicks away with Expedia.
The Latest Eastern South Dakota vacation packages
Price found within the past 48 hours. Click for updated prices.
Historic Twin Tudors Inn
per person
Sep 19 - Sep 22
found 1 day ago
Roundtrip flight included
Phoenix (PHX) to Sioux Falls (FSD)
8.8/10 Excellent! (3 reviews)
We were upgraded to staying at the Victorian Inn- i would highly recommended. The house is charming and located in the historic downtown of Sioux Falls.
Reviewed on Jun 16, 2025
Hotel On Phillips
Downtown Sioux Falls
per person
Sep 19 - Sep 22
found 1 day ago
Roundtrip flight included
Phoenix (PHX) to Sioux Falls (FSD)
9.6/10 Exceptional! (1,120 reviews)
We’ve stayed here twice and I absolutely love this hotel. The lobby, bar, and rooms are all gorgeous!
Each time, we requested a high floor, and the front desk was so accommodating, putting us on the top floor with nice views. I also appreciate the thoughtful touches in the rooms like the cozy robes, bigger mini-fridges, and the lounge chairs at the foot of the bed were perfect for setting all our things.
You really can’t beat the location. It’s within walking distance of almost everything downtown. Thank you for everything!
Reviewed on Aug 12, 2025
Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr
per person
Sep 19 - Sep 22
found 1 day ago
Roundtrip flight included
Phoenix (PHX) to Sioux Falls (FSD)
7.6/10 Good! (1,339 reviews)
Water park was a blast for the kids. The rooms need updated bad. Not in best shape. they are panting the outside so they are trying. But room need major help.
Reviewed on Aug 12, 2025
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View all tripsWhere to stay in Eastern South Dakota
Find the best Eastern South Dakota areas and neighborhoods for the activities you enjoy most. Learn more about Eastern South Dakota
Downtown Sioux Falls
4.5/5(108 area reviews)
While visiting Downtown Sioux Falls, you might make a stop by sights like Washington Pavilion of Arts and Science and Michelangelo's David.
Discover the most popular places to visit in Eastern South Dakota
Falls Park
Falls Park is just one of the places to see in Sioux Falls, so why not enjoy the other things to explore during your travels? Attend a sporting event or discover the area's beautiful waterfalls.
Corn Palace
You can find out about the history of Mitchell with a stop at Corn Palace. While in this family-friendly area, you can savor the top-notch restaurants.
Great Plains Zoo
Why not visit the native and exotic animals who live at Great Plains Zoo during your travels in Sioux Falls? Attend a sporting event or discover the area's beautiful waterfalls.
Eastern South Dakota Hotel Deals
Hotel On Phillips
100 N Phillips Ave, Sioux Falls, SD
Fully refundableReserve now, pay when you stay
$188 nightly
The price is $208 total per night from Sep 2 to Sep 3
$208 total
Sep 2 - Sep 3
Total includes taxes and fees
9.4/10 Exceptional! (1,138 reviews)
Perfect Location!
"Hotel on Phillips is a great hotel. The location gives you access to restaurants and the main drag is walkable. Front Desk staff had a great attitude and gave us helpful information. Would recommend this hotel to anyone visiting Sioux Falls."
Reviewed on Aug 11, 2025
AeroStay Hotel
2821 N Jaycee Lane, Sioux Falls, SD
Fully refundableReserve now, pay when you stay
$150 nightly
The price is $166 total per night from Aug 21 to Aug 22
$166 total
Aug 21 - Aug 22
Total includes taxes and fees
8.8/10 Excellent! (1,012 reviews)
"Convenient and comfortable"
Reviewed on Aug 11, 2025
Kelly Inn & Suites Mitchell South Dakota
1010 Cabela Drive, Mitchell, SD
Fully refundableReserve now, pay when you stay
$128 nightly
The price is $141 total per night from Aug 17 to Aug 18
$141 total
Aug 17 - Aug 18
Total includes taxes and fees
8/10 Very Good! (1,024 reviews)
"Nice property, but check in was lengthy."
Reviewed on Aug 11, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.