Eastern South Dakota Vacations from $533

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Your Eastern South Dakota Vacation

Locking in one of our vacation packages to Eastern South Dakota makes it a breeze to see and do more. Get set to experience this exciting destination's rural countryside and beyond. Your trip to Eastern South Dakota wouldn't be complete without getting to some of its best cities, starting with Sioux Falls. Some of the most popular attractions here include Denny Sanford Premier Center and Empire Mall. Mitchell is another favorite with Eastern South Dakota travelers. Visitors to this exciting destination enjoy Corn Palace and Mitchell Aquatic Center. Start packing your bags, because your Eastern South Dakota vacation is just a few clicks away with Expedia.

The Latest Eastern South Dakota vacation packages

Price found within the past 48 hours. Click for updated prices.
Gateway Park Hotel and Suites
Historic Twin Tudors Inn
Hotel On Phillips
Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr
Clubhouse Hotel Suites Sioux Falls
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Where to stay in Eastern South Dakota

Find the best Eastern South Dakota areas and neighborhoods for the activities you enjoy most. Learn more about Eastern South Dakota

Discover the most popular places to visit in Eastern South Dakota

Eastern South Dakota Hotel Deals

Hotel On Phillips

Hotel On Phillips

2.5 out of 5
100 N Phillips Ave, Sioux Falls, SD
Fully refundableReserve now, pay when you stay
$188 nightly
The price is $208 total per night from Sep 2 to Sep 3
$208 total
Sep 2 - Sep 3
Total includes taxes and fees
9.4/10 Exceptional! (1,138 reviews)
Perfect Location!
"Hotel on Phillips is a great hotel. The location gives you access to restaurants and the main drag is walkable. Front Desk staff had a great attitude and gave us helpful information. Would recommend this hotel to anyone visiting Sioux Falls."

Reviewed on Aug 11, 2025

Hotel On Phillips
AeroStay Hotel

AeroStay Hotel

2.5 out of 5
2821 N Jaycee Lane, Sioux Falls, SD
Fully refundableReserve now, pay when you stay
$150 nightly
The price is $166 total per night from Aug 21 to Aug 22
$166 total
Aug 21 - Aug 22
Total includes taxes and fees
8.8/10 Excellent! (1,012 reviews)
"Convenient and comfortable"

Reviewed on Aug 11, 2025

AeroStay Hotel
Kelly Inn & Suites Mitchell South Dakota

Kelly Inn & Suites Mitchell South Dakota

2.5 out of 5
1010 Cabela Drive, Mitchell, SD
Fully refundableReserve now, pay when you stay
$128 nightly
The price is $141 total per night from Aug 17 to Aug 18
$141 total
Aug 17 - Aug 18
Total includes taxes and fees
8/10 Very Good! (1,024 reviews)
"Nice property, but check in was lengthy."

Reviewed on Aug 11, 2025

Kelly Inn & Suites Mitchell South Dakota
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.